Vísindagreinar
Í greinasafninu hér fyrir neðan má finna ritrýndar vísindagreinar sem gefnar hafa verið út á undanförnum árum og byggja á myndgreiningu Hjartaverndar. Um er að ræða fjölbreytt efni þar sem myndgreiningu hefur verið beitt í ýmsum rannsóknum, m.a. Öldrunarrannsókninni (AGES), Áhættuþátttakönnuninni (REFINE) og Afkomendarannsókninni (OFFGEN) þar sem myndir hafa verið teknar af öllum meginlíffærakerfum, þ.m.t. heila- og taugakerfi, stoðkerfi ásamt hjarta- og æðakerfi. Rannsóknarstarfið heldur áfram og eru í hverjum mánuði birtur fjöldi vísindagreina í ritrýndum vísindatímaritum.
Greinasafn
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics.
Harris TB, Launer LJ, Eiriksdottir G, Kjartansson O, Jonsson PV, Sigurdsson G, Thorgeirsson G, Aspelund T, Garcia ME, Cotch MF, Hoffman HJ, Gudnason V. Am J Epidemiol. 2007 May 1;165(9):1076-87.
Increasing sex difference in bone strength in old age: The Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK).
Sigurdsson G, Aspelund T, Chang M, Jonsdottir B, Sigurdsson S, Eiriksdottir G, Gudmundsson A, Harris TB, Gudnason V, Lang TF. Bone. 2006 Sep;39(3):644-51.
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O’Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stančáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J6, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. Nat Commun. 2017 Nov 7;8(1):1414. doi: 10.1038/s41467-017-01008-2.
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2.
Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellström D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. J Bone Miner Res. 2016 Dec;31(12):2085-2097. doi: 10.1002/jbmr.2913.
Hip fractures and bone mineral density in the elderly–importance of serum 25-hydroxyvitamin D.
Steingrimsdottir L, Halldorsson TI, Siggeirsdottir K, Cotch MF, Einarsdottir BO, Eiriksdottir G, Sigurdsson S, Launer LJ, Harris TB, Gudnason V, Sigurdsson G. PLoS One. 2014 Mar 12;9(3):e91122. doi: 10.1371/journal.pone.0091122
Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adults
Shanbhag SM, Greve AM, Aspelund T, Schelbert EB, Cao JJ, Danielsen R, Þorgeirsson G, Sigurðsson S, Eiríksdóttir G, Harris TB, Launer LJ, Guðnason V, Arai AE . Eur Heart J. 2018 Nov 16. doi: 10.1093.
Identification of common variants associated with human hippocampal and intracranial volumes.
Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Mattingsdal M, Mohnke S, Maniega SM, Nho K, Nugent AC, O’Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M, Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N, Johnson MP, Kasperaviciute D, Kent JW Jr, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van den Heuvel M, van der Wee NJ, Van Haren NE, Veltman JA, Völzke H, Walker R, Westlye LT, Whelan CD, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Heinz A, Jack CR Jr, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative; EPIGEN Consortium; IMAGEN Consortium; Saguenay Youth Study Group, Bis JC, Ikram MA, Smith AV, Gudnason V, Tzourio C, Vernooij MW, Launer LJ, DeCarli C, Seshadri S; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Andreassen OA, Apostolova LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de Zubicaray GI, Deary IJ, Donohoe G, de Geus EJ, Espeseth T, Fernández G, Glahn DC, Grabe HJ, Hardy J, Hulshoff Pol HE, Jenkinson M, Kahn RS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B, Nichols TE, Ophoff RA, Paus T, Pausova Z, Penninx BW, Potkin SG, Sämann PG, Saykin AJ, Schumann G, Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B, Wright MJ, Thompson PM; Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium. Nat Genet. 2012 Apr 15;44(5):552-61. doi: 10.1038/ng.2250.
Interstitial lung abnormalities and self-reported health and functional status.
Axelsson GT, Putman RK, Araki T, Sigurdsson S, Gudmundsson EF, Eiriksdottir G, Aspelund T, Miller ER, Launer LJ, Harris TB, Hatabu H, Gudnason V, Hunninghake GM, Gudmundsson G. Thorax. 2018 Sep;73(9):884-886. doi: 10.1136/thoraxjnl-2017-210956.
Advanced quantitative methods in correlating sarcopenic muscle degeneration with lower extremity function biometrics and comorbidities.
Kyle Edmunds , Magnús Gíslason, Sigurður Sigurðsson, Vilmundur Guðnason, Tamara Harris, Ugo Carraro, Paolo Gargiulo. Plos One. March 7, 2018https://doi.org/10.1371/journal.pone.0193241
Common genetic variation in the 3′-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.
Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Yasmin, Rietzschel ER, Tanaka T, Liu Y, Parsa A, Najjar SS, O’Shaughnessy KM, Sigurdsson S, De Buyzere ML, Larson MG, Sie MP, Andrews JS, Post WS, Mattace-Raso FU, McEniery CM, Eiriksdottir G, Segers P, Vasan RS, van Rijn MJ, Howard TD, McArdle PF, Dehghan A, Jewell ES, Newhouse SJ, Bekaert S, Hamburg NM, Newman AB, Hofman A, Scuteri A, De Bacquer D, Ikram MA, Psaty BM, Fuchsberger C, Olden M, Wain LV, Elliott P, Smith NL, Felix JF, Erdmann J, Vita JA, Sutton-Tyrrell K, Sijbrands EJ, Sanna S, Launer LJ, De Meyer T, Johnson AD, Schut AF, Herrington DM, Rivadeneira F, Uda M, Wilkinson IB, Aspelund T, Gillebert TC, Van Bortel L, Benjamin EJ, Oostra BA, Ding J, Gibson Q, Uitterlinden AG, Abecasis GR, Cockcroft JR, Gudnason V, De Backer GG, Ferrucci L, Harris TB, Shuldiner AR, van Duijn CM, Levy D, Lakatta EG, Witteman JC. Circ Cardiovasc Genet. 2012 Feb 1;5(1):81-90. doi: 10.1161/CIRCGENETICS.111.959817.
Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults.
Frank-Wilson AW, Chalhoub D, Figueiredo P, Jónsson PV, Siggeirsdóttir K, Sigurdsson S, Eiriksdottir G, Guðnason V, Launer L, Harris TB; AGES-Reykjavik Study. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):931-938. doi: 10.
Longitudinal Changes in Size and Composition of Carotid Artery Plaques Using Ultrasound: Adaptation and Validation of Methods (Inter- and Intraobserver Variability)
Gudlaug Bjornsdottir, Sigurdur Sigurdsson, Ran Sturlaugsdottir, Agnes Gudmundsdottir, Gudny Eiriksdottir, Bolli Thorsson, Thor Aspelund, Tomas Gustavsson, Lenore J. Launer, Tamara B. Harris, Vilmundur Gudnason. Journal For Vascular Ultrasound (SVU), 2014, Volume: 38 issue: 4, page(s): 198-208.
Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study.
Ding J, Sigurðsson S, Jónsson PV, Eiriksdottir G, Charidimou A4, Lopez OL,, van Buchem MA, Guðnason V, Launer LJ. JAMA Neurol. 2017 Sep 1;74(9):1105-1112. doi: 10.1001/jamaneurol.2017.1397.
Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.
Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, van Buchem MA, van der Grond J, Smith AV, Hegenscheid K, Aggarwal NT, de Andrade M, Atkinson EJ, Beekman M, Beiser AS, Blanton SH, Boerwinkle E, Brickman AM, Bryan RN, Chauhan G, Chen CP, Chouraki V, de Craen AJ, Crivello F, Deary IJ, Deelen J, De Jager PL, Dufouil C, Elkind MS, Evans DA, Freudenberger P, Gottesman RF, Guðnason V, Habes M, Heckbert SR, Heiss G, Hilal S, Hofer E, Hofman A, Ibrahim-Verbaas CA, Knopman DS, Lewis CE, Liao J, Liewald DC, Luciano M, van der Lugt A, Martinez OO, Mayeux R, Mazoyer B, Nalls M, Nauck M, Niessen WJ, Oostra BA, Psaty BM, Rice KM, Rotter JI, von Sarnowski B, Schmidt H, Schreiner PJ, Schuur M, Sidney SS, Sigurdsson S, Slagboom PE, Stott DJ, van Swieten JC, Teumer A, Töglhofer AM, Traylor M, Trompet S, Turner ST, Tzourio C, Uh HW, Uitterlinden AG, Vernooij MW, Wang JJ, Wong TY, Wardlaw JM, Windham BG, Wittfeld K, Wolf C, Wright CB, Yang Q, Zhao W, Zijdenbos A, Jukema JW, Sacco RL, Kardia SL, Amouyel P, Mosley TH, Longstreth WT Jr, DeCarli CC, van Duijn CM, Schmidt R, Launer LJ, Grabe HJ, Seshadri SS, Ikram MA, Fornage M. Circ Cardiovasc Genet. 2015 Apr;8(2):398-409. doi: 10.1161/CIRCGENETICS.114.000858. Epub 2015 Feb 7.
Genetic overlap between vascular pathologies and Alzheimer’s dementia and potential causal mechanisms.
Lin YF, Smith AV, Aspelund T, Betensky RA, Smoller JW, Gudnason V, Launer LJ, Blacker D. Alzheimers Dement. 2018 Sep 18. pii: S1552-5260(18)33493-9. doi: 10.1016/j.jalz.2018.08.002
Interstitial lung abnormalities and physical function.
Axelsson GT, Putman RK, Miller ER, Araki T, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Siggeirsdottir K, Aspelund T, Launer LJ, Harris TB, Hatabu H, Gudnason V, Hunninghake GM, Gudmundsson G,.ERJ Open Res. 2018 Sep 3;4(3). pii: 00057-2018. doi: 10.1183/23120541.00057-2018.
Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity.
Woods GN, Ewing SK, Sigurdsson S, Kado DM, Ix JH, Hue TF, Eiriksdottir G, Xu K, Gudnason V, Lang TF, Vittinghoff E, Harris TB, Rosen CJ, Li X, Schwartz AV,. J Bone Miner Res. 2018 Aug 3. doi: 10.1002/jbmr.3562.
Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.
Jian X1, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu FC, Nho K, Hofer E, Hagenaars SP, Nyquist PA, Mishra A, Adams HHH, Li S, Teumer A, Zhao W, Freedman BI, Saba Y, Yanek LR, Chauhan G, van Buchem MA, Cushman M, Royle NA, Bryan RN, Niessen WJ, Windham BG, DeStefano AL, Habes M, Heckbert SR, Palmer ND, Lewis CE, Eiriksdottir G, Maillard P, Mathias RA, Homuth G, Valdés-Hernández MDC, Divers J, Beiser AS, Langner S, Rice KM, Bastin ME, Yang Q, Maldjian JA, Starr JM, Sidney S, Risacher SL, Uitterlinden AG, Gudnason VG, Nauck M, Rotter JI, Schreiner PJ, Boerwinkle E, van Duijn CM, Mazoyer B, von Sarnowski B, Gottesman RF, Levy D, Sigurdsson S, Vernooij MW, Turner ST, Schmidt R, Wardlaw JM, Psaty BM, Mosley TH, DeCarli CS, Saykin AJ, Bowden DW, Becker DM, Deary IJ, Schmidt H, Kardia SLR, Ikram MA, Debette S, Grabe HJ, Longstreth WT Jr, Seshadri S, Launer LJ, Fornage M; neuroCHARGE Working Group. Stroke. 2018 Aug;49(8):1812-1819. doi: 10.1161/STROKEAHA.118.020689
The AGES-Reykjavik Study suggests that change in kidney measures is associated with subclinical brain pathology in older community-dwelling persons.
Sedaghat S, Ding J, Eiriksdottir G, van Buchem MA, Sigurdsson S, Ikram MA, Meirelles O, Gudnason V, Levey AS, Launer LJ. Kidney Int. 2018 Sep;94(3):608-615. doi: 10.1016/j.kint.2018.04.022
Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: the REFINE-Reykjavik study with comparison with the Tromsø study.
Thorsson B, Eiriksdottir G, Sigurdsson S, Gudmundsson EF, Bots ML, Aspelund T, Arntzen KA, Mathiesen EB, Gudnason V. BMJ Open. 2018 May 31;8(5):e019385. doi: 10.1136/bmjopen-2017-019385.
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study.
Marques EA, Carballido-Gamio J, Gudnason V, Sigurdsson G, Sigurdsson S, Aspelund T, Siggeirsdottir K, Launer L, Eiriksdottir G, Lang T, Harris TB. Bone. 2018 Sep;114:72-80. doi: 10.1016/j.bone.2018.05.016
Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1).
Charidimou A, Shams S, Romero JR, Ding J, Veltkamp R, Horstmann S, Eiriksdottir G, van Buchem MA, Gudnason V, Himali JJ, Gurol ME, Viswanathan A, Imaizumi T, Vernooij MW, Seshadri S, Greenberg SM, Benavente OR, Launer LJ, Shoamanesh A; International META-MICROBLEEDS Initiative. Int J Stroke. 2018 Jul;13(5):454-468. doi: 10.1177/1747493017751931.
Cigarette smoking and hip volumetric bone mineral density and cortical volume loss in older adults: The AGES-Reykjavik study.
Marques EA1, Elbejjani M, Gudnason V, Sigurdsson G, Lang T, Sigurdsson S, Aspelund T, Siggeirsdottir K, Launer L, Eiriksdottir G, Harris TB. Bone. 2018 Mar;108:186-192. doi: 10.1016/j.bone.2018.01.014.
Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study.
Thorsteinsdottir S, Lund SH, Lindqvist EK, Thordardottir M, Sigurdsson G, Costello R, Burton D, Steingrimsdottir H, Gudnason V, Eiriksdottir G, Siggeirsdottir K, Harris TB, Landgren O, Kristinsson SY. Blood Adv. 2017 Dec 21;1(27):2790-2798. doi: 10.1182/bloodadvances.2017010454
Predictors of carotid plaque progression over a 4-year follow-up in the Reykjavik REFINE-study.
Sturlaugsdottir R, Aspelund T, Bjornsdottir G, Sigurdsson S, Thorsson B, Eiriksdottir G, Gudnason V. Atherosclerosis. 2018 Feb;269:57-62. doi: 10.1016/j.atherosclerosis.2017.12.005.
Sex hormones are negatively associated with vertebral bone marrow fat.
Mistry SD, Woods GN, Sigurdsson S, Ewing SK, Hue TF, Eiriksdottir G, Xu K, Hilton JF, Kado DM, Gudnason V, Harris TB, Rosen CJ, Lang TF, Li X, Schwartz AV. Bone. 2018 Mar;108:20-24. doi: 10.1016/j.bone.2017.12.009.
Differential associations between retinal signs and CMBs by location: The AGES-Reykjavik Study.
Qiu C, Ding J, Sigurdsson S, Fisher DE, Zhang Q, Eiriksdottir G, Klein R, van Buchem MA, Gudnason V, Cotch MF, Launer LJ. Neurology. 2018 Jan 9;90(2):e142-e148. doi: 10.1212/WNL.0000000000004792.
Atrial fibrillation is associated with decreased total cerebral blood flow and brain perfusion.
Gardarsdottir M, Sigurdsson S, Aspelund T, Rokita H, Launer LJ, Gudnason V, Arnar DO. Europace. 2017 Aug 9. doi: 10.1093/europace/eux220.
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes.
Putman RK, Gudmundsson G, Araki T, Nishino M, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Aspelund T, Ross JC, San José Estépar R, Miller ER, Yamada Y, Yanagawa M, Tomiyama N, Launer LJ, Harris TB, El-Chemaly S, Raby BA, Cho MH, Rosas IO, Washko GR, Schwartz DA, Silverman EK, Gudnason V, Hatabu H, Hunninghake GM. Eur Respir J. 2017 Sep 11;50(3). pii: 1700537. doi: 10.1183/13993003.00537-2017.
Oral glucose tolerance test predicts increased carotid plaque burden in patients with acute coronary syndrome.
Bjarnason TA, Hafthorsson SO, Kristinsdottir LB, Oskarsdottir ES, Aspelund T, Sigurdsson S, Gudnason V, Andersen K. PLoS One. 2017 Aug 30;12(8):e0183839. doi: 10.1371/journal.pone.0183839
Incidence of Brain Infarcts, Cognitive Change, and Risk of Dementia in the General Population: The AGES-Reykjavik Study (Age Gene/Environment Susceptibility-Reykjavik Study).
Sigurdsson S, Aspelund T, Kjartansson O, Gudmundsson EF, Jonsdottir MK, Eiriksdottir G, Jonsson PV, van Buchem MA, Gudnason V, Launer LJ. Stroke. 2017 Sep;48(9):2353-2360. doi: 10.1161/STROKEAHA.117.017357
Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopy.
Xu K, Sigurdsson S, Gudnason V, Hue T, Schwartz A, Li X. Magn Reson Med. 2018 Mar;79(3):1722-1729. doi: 10.1002/mrm.26828.
Heritability and genome-wide associations studies of cerebral blood flow in the general population.
Ikram MA, Zonneveld HI, Roshchupkin G, Smith AV, Franco OH, Sigurdsson S, van Duijn C, Uitterlinden AG, Launer LJ, Vernooij MW, Gudnason V, Adams HH. J Cereb Blood Flow Metab. 2018 Sep;38(9):1598-1608. doi: 10.1177/0271678X17715861
Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification.
Afshar M, Luk K, Do R, Dufresne L, Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q, Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich SS, Engert JC, Gudnason V, O’Donnell CJ, Post WS, Thanassoulis G; CHARGE Extracoronary Calcium Working Group. J Am Coll Cardiol. 2017 Jun 20;69(24):2941-2948. doi: 10.1016/j.jacc.2017.04.051
The AGES-Reykjavik study atlases: Non-linear multi-spectral template and atlases for studies of the ageing brain.
Forsberg L, Sigurdsson S, Fredriksson J, Egilsdottir A, Oskarsdottir B, Kjartansson O, van Buchem MA, Launer LJ, Gudnason V, Zijdenbos A. Med Image Anal. 2017 Jul;39:133-144. doi: 10.1016/j.media.2017.04.009
Space and location of cerebral microbleeds, cognitive decline, and dementia in the community.
Ding J, Sigurðsson S, Jónsson PV, Eiriksdottir G, Meirelles O, Kjartansson O, Lopez OL, van Buchem MA, Gudnason V, Launer LJ. Neurology. 2017 May 30;88(22):2089-2097. doi: 10.1212/WNL.0000000000003983
Associations of 24-hour sleep duration and CT-derived measurements of muscle and bone: The AGES-Reykjavik Study.
Marques EA, Figueiredo P, Gudnason V, Lang T, Sigurdsson G, Sigurdsson S, Aspelund T, Siggeirsdottir K, Launer L, Eiriksdottir G, Harris TB. Exp Gerontol. 2017 Jul;93:1-6. doi: 10.1016/j.exger.2017.04.002
Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.
Spauwen PJ, Murphy RA, Jónsson PV, Sigurdsson S, Garcia ME, Eiriksdottir G, van Boxtel MP, Lopez OL, Gudnason V, Harris TB, Launer LJ. Age Ageing. 2017 Mar 1;46(2):250-257. doi: 10.1093/ageing/afw219.
Proximal Femur Volumetric Bone Mineral Density and Mortality: 13 Years of Follow-Up of the AGES-Reykjavik Study.
Marques EA, Elbejjani M, Gudnason V, Sigurdsson G, Lang T, Sigurdsson S, Aspelund T, Meirelles O, Siggeirsdottir K, Launer L, Eiriksdottir G, Harris TB. J Bone Miner Res. 2017 Jun;32(6):1237-1242. doi: 10.1002/jbmr.3104
Prevalence and determinants of carotid plaque in the cross-sectional REFINE-Reykjavik study.
Sturlaugsdottir R, Aspelund T, Bjornsdottir G, Sigurdsson S, Thorsson B, Eiriksdottir G, Gudnason V. BMJ Open. 2016 Nov 24;6(11):e012457. doi: 10.1136/bmjopen-2016-012457
Long-Term Hormone Replacement Therapy Is Associated with Low Coronary Artery Calcium Levels in a Cohort of Older Women: The Age, Gene/Environment Susceptibility-Reykjavik Study.
Gudmundsson A, Aspelund T, Sigurdsson G, Harris T, Launer LJ, Gudnason V, Jonsson H. J Am Geriatr Soc. 2017 Jan;65(1):200-206. doi: 10.1111/jgs.14461
Cardiac and Carotid Markers Link With Accelerated Brain Atrophy: The AGES-Reykjavik Study (Age, Gene/Environment Susceptibility-Reykjavik).
Sabayan B, van Buchem MA, Sigurdsson S, Zhang Q, Meirelles O, Harris TB, Gudnason V, Arai AE, Launer LJ. Sabayan B, van Buchem MA, Sigurdsson S, Zhang Q, Meirelles O, Harris TB, Gudnason V, Arai AE, Launer LJ. Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2246-2251.
Allometric scaling of brain regions to intra-cranial volume: An epidemiological MRI study.
de Jong LW, Vidal JS, Forsberg LE, Zijdenbos AP, Haight T; Alzheimer’s Disease Neuroimaging Initiative, Sigurdsson S, Gudnason V, van Buchem MA, Launer LJ. Hum Brain Mapp. 2017 Jan;38(1):151-164. doi: 10.1002/hbm.23351
Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study.
Gudmundsson G, Margretardottir OB, Sigurdsson MI, Harris TB, Launer LJ, Sigurdsson S, Olafsson O, Aspelund T, Gudnason V. Atherosclerosis. 2016 Sep;252:122-127. doi: 10.1016/j.atherosclerosis.2016.07.919.
Pineal Gland Volume Assessed by MRI and Its Correlation with 6-Sulfatoxymelatonin Levels among Older Men.
Sigurdardottir LG, Markt SC, Sigurdsson S, Aspelund T, Fall K, Schernhammer E, Rider JR, Launer L, Harris T, Stampfer MJ, Gudnason V, Czeisler CA, Lockley SW, Valdimarsdottir UA, Mucci LA. J Biol Rhythms. 2016 Oct;31(5):461-9. doi: 10.1177/0748730416656948
Physical activity and incidence of sarcopenia: the population-based AGES-Reykjavik Study.
Mijnarends DM, Koster A, Schols JM, Meijers JM, Halfens RJ, Gudnason V, Eiriksdottir G, Siggeirsdottir K, Sigurdsson S, Jónsson PV, Meirelles O, Harris T. Age Ageing. 2016 Sep;45(5):614-20. doi: 10.1093/ageing/afw090
Interactive graph-cut segmentation for fast creation of finite element models from clinical ct data for hip fracture prediction.
Pauchard Y, Fitze T, Browarnik D, Eskandari A, Pauchard I, Enns-Bray W, Pálsson H, Sigurdsson S, Ferguson SJ, Harris TB, Gudnason V, Helgason B. Comput Methods Biomech Biomed Engin. 2016 Dec;19(16):1693-1703
Late-life brain volume: a life-course approach. The AGES-Reykjavik study.
Muller M, Sigurdsson S, Kjartansson O, Gunnarsdottir I, Thorsdottir I, Harris TB, van Buchem M, Gudnason V, Launer LJ; Age, Gene/Environment Susceptibility-Reykjavik Study Investigators. Neurobiol Aging. 2016 May;41:86-92. doi: 10.1016/j.neurobiolaging.2016.02.012.
Midlife Cardiovascular Risk Factors and Late-Life Unrecognized and Recognized Myocardial Infarction Detect by Cardiac Magnetic Resonance: ICELAND-MI, the AGES-Reykjavik Study.
McAreavey D, Vidal JS, Aspelund T, Eiriksdottir G, Schelbert EB, Kjartansson O, Cao JJ, Thorgeirsson G, Sigurdsson S, Garcia M, Harris TB, Launer LJ, Gudnason V, Arai AE. J Am Heart Assoc. 2016 Feb 12;5(2). pii: e002420. doi: 10.1161/JAHA.115.002420.
Incidence and prevalence of total joint replacements due to osteoarthritis in the elderly: risk factors and factors associated with late life prevalence in the AGES-Reykjavik Study
Jonsson H, Olafsdottir S, Sigurdardottir S, Aspelund T, Eiriksdottir G, Sigurdsson S, Harris TB, Launer L, Gudnason V. BMC Musculoskelet Disord. 2016 Jan 12;17:14. doi: 10.1186/s12891-016-0864-7.
Feasibility of Using Pseudo-Continuous Arterial Spin Labeling Perfusion in a Geriatric Population at 1.5 Tesla.
Sigurdsson S, Forsberg L, Aspelund T, van der Geest RJ, van Buchem MA, Launer LJ, Gudnason V, van Osch MJ. PLoS One. 2015 Dec 14;10(12):e0144743. doi: 10.1371/journal.pone.0144743
Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory.
Cooper LL, Woodard T, Sigurdsson S, van Buchem MA, Torjesen AA, Inker LA, Aspelund T, Eiriksdottir G, Harris TB, Gudnason V, Launer LJ, Mitchell GF. Hypertension. 2016 Jan;67(1):176-82. doi: 10.1161/HYPERTENSIONAHA.115.06398
Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study.
van Sloten TT, Mitchell GF, Sigurdsson S, van Buchem MA, Jonsson PV, Garcia ME, Harris TB, Henry RM, Levey AS, Stehouwer CD, Gudnason V, Launer LJ. J Psychiatry Neurosci. 2016 Apr;41(3):162-8.
White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BF, Wolf C, Yang Q, Adams HH, Amouyel P, Beiser A, Buckley BM, Callisaya M, Chauhan G, de Craen AJ, Dufouil C, van Duijn CM, Ford I, Freudenberger P, Gottesman RF, Gudnason V, Heiss G, Hofman A, Lumley T, Martinez O, Mazoyer B, Moran C, Niessen WJ, Phan T, Psaty BM, Satizabal CL, Sattar N, Schilling S, Shibata DK, Slagboom PE, Smith A, Stott DJ, Taylor KD, Thomson R, Töglhofer AM, Tzourio C, van Buchem M, Wang J, Westendorp RG, Windham BG, Vernooij MW, Zijdenbos A, Beare R, Debette S, Ikram MA, Jukema JW, Launer LJ, Longstreth WT Jr, Mosley TH, Seshadri S, Schmidt H, Schmidt R; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Stroke. 2015 Nov;46(11):3048-57. doi: 10.1161/STROKEAHA.115.009252.
Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study.
Arnardottir NY, Koster A, Domelen DRV, Brychta RJ, Caserotti P, Eiriksdottir G, Sverrisdottir JE, Sigurdsson S, Johannsson E, Chen KY, Gudnason V, Harris TB, Launer LJ, Sveinsson T. Behav Brain Res. 2016 Jan 1;296:118-124. doi: 10.1016/j.bbr.2015.09.005.
Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementia
Geerlings MI, Sigurdsson S, Eiriksdottir G, Garcia ME, Harris TB, Gudnason V, Launer LJ. Neurology. 2015 Sep 15;85(11):976-83. doi: 10.1212/WNL.0000000000001931
N-terminal pro-brain natriuretic peptide and abnormal brain aging: The AGES-Reykjavik Study.
Sabayan B, van Buchem MA, de Craen AJ, Sigurdsson S, Zhang Q, Harris TB, Gudnason V, Arai AE, Launer LJ. Neurology. 2015 Sep 1;85(9):813-20. doi: 10.1212/WNL.0000000000001885
Carotid atherosclerosis and cardiovascular health metrics in old subjects from the AGES-Reykjavik study.
Sturlaugsdottir R, Aspelund T, Bjornsdottir G, Sigurdsson S, Eiriksdottir G, Imai CM, Garcia M, Launer LJ, Harris TB, Gudnason V. Atherosclerosis. 2015 Sep;242(1):65-70. doi: 10.1016/j.atherosclerosis.2015.06.043
Carotid arterial stiffness and risk of incident cerebral microbleeds in older people: the Age, Gene/Environment Susceptibility (AGES)-Reykjavik study.
Ding J, Mitchell GF, Bots ML, Sigurdsson S, Harris TB, Garcia M, Eiriksdottir G, van Buchem MA, Gudnason V, Launer LJ. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1889-95. doi: 10.1161/ATVBAHA.115.305451
Cod liver oil consumption at different periods of life and bone mineral density in old age.
Eysteinsdottir T, Halldorsson TI, Thorsdottir I, Sigurdsson G, Sigurdsson S, Harris T, Launer LJ, Gudnason V, Gunnarsdottir I, Steingrimsdottir L. Br J Nutr. 2015 Jul;114(2):248-56. doi: 10.1017/S0007114515001397.
Risk Factors Associated With Incident Cerebral Microbleeds According to Location in Older People: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.
Ding J, Sigurdsson S, Garcia M, Phillips CL, Eiriksdottir G, Gudnason V, van Buchem MA, Launer LJ. JAMA Neurol. 2015 Jun;72(6):682-8. doi: 10.1001/jamaneurol.2015.0174
Overweight and Obesity in Midlife and Brain Structure and Dementia 26 Years Later: The AGES-Reykjavik Study.
Albanese E, Davis B, Jonsson PV, Chang M, Aspelund T, Garcia M, Harris T, Gudnason V, Launer LJ. Am J Epidemiol. 2015 May 1;181(9):672-9. doi: 10.1093/aje/kwu331
Relations between aortic stiffness and left ventricular structure and function in older participants in the Age, Gene/Environment Susceptibility–Reykjavik Study.
Bell V, Sigurdsson S, Westenberg JJ, Gotal JD, Torjesen AA, Aspelund T, Launer LJ, Harris TB, Gudnason V, de Roos A, Mitchell GF. Circ Cardiovasc Imaging. 2015 Apr;8(4):e003039. doi: 10.1161/CIRCIMAGING.114.003039.
Plasma phospholipid fatty acids and fish-oil consumption in relation to osteoporotic fracture risk in older adults: the Age, Gene/Environment Susceptibility Study.
Harris TB, Song X, Reinders I, Lang TF, Garcia ME, Siggeirsdottir K, Sigurdsson S, Gudnason V, Eiriksdottir G, Sigurdsson G, Steingrimsdottir L, Aspelund T, Brouwer IA, Murphy RA. Am J Clin Nutr. 2015 May;101(5):947-55. doi: 10.3945/ajcn.114.087502.
Fat distribution and mortality: the AGES-Reykjavik Study.
Koster A1, Murphy RA, Eiriksdottir G, Aspelund T, Sigurdsson S, Lang TF, Gudnason V, Launer LJ, Harris TB. Obesity (Silver Spring). 2015 Apr;23(4):893-7. doi: 10.1002/oby.21028.
Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study.
van Sloten TT, Sigurdsson S, van Buchem MA, Phillips CL, Jonsson PV, Ding J, Schram MT, Harris TB, Gudnason V, Launer LJ. Am J Psychiatry. 2015 Jun;172(6):570-8. doi: 10.1176/appi.ajp.2014.14050578.
Cardiac hemodynamics are linked with structural and functional features of brain aging: the age, gene/environment susceptibility (AGES)-Reykjavik Study.
Sabayan B, van Buchem MA, Sigurdsson S, Zhang Q, Harris TB, Gudnason V, Arai AE, Launer LJ. J Am Heart Assoc. 2015 Jan 27;4(1):e001294. doi: 10.1161/JAHA.114.001294.
Longitudinal and circumferential strain of the proximal aorta.
Bell V, Mitchell WA, Sigurðsson S, Westenberg JJ, Gotal JD, Torjesen AA, Aspelund T, Launer LJ, de Roos A, Gudnason V, Harris TB, Mitchell GF. J Am Heart Assoc. 2014 Dec;3(6):e001536. doi: 10.1161/JAHA.114.001536.
Plasma phospholipid PUFAs are associated with greater muscle and knee extension strength but not with changes in muscle parameters in older adults.
Reinders I, Song X, Visser M, Eiriksdottir G, Gudnason V, Sigurdsson S, Aspelund T, Siggeirsdottir K, Brouwer IA, Harris TB, Murphy RA. J Nutr. 2015 Jan;145(1):105-12. doi: 10.3945/jn.114.200337.
Adipose tissue, muscle, and function: potential mediators of associations between body weight and mortality in older adults with type 2 diabetes.
Murphy RA, Reinders I, Garcia ME, Eiriksdottir G, Launer LJ, Benediktsson R, Gudnason V, Jonsson PV, Harris TB; Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik). Diabetes Care. 2014 Dec;37(12):3213-9. doi: 10.2337/dc14-0293.
Mediation analysis of aortic stiffness and renal microvascular function.
Woodard T, Sigurdsson S, Gotal JD, Torjesen AA, Inker LA, Aspelund T, Eiriksdottir G, Gudnason V, Harris TB, Launer LJ, Levey AS, Mitchell GF. J Am Soc Nephrol. 2015 May;26(5):1181-7. doi: 10.1681/ASN.2014050450.
Age-related macular degeneration and mortality in community-dwelling elders: the age, gene/environment susceptibility Reykjavik study.
Fisher DE, Jonasson F, Eiriksdottir G, Sigurdsson S, Klein R, Launer LJ, Gudnason V, Cotch MF. Ophthalmology. 2015 Feb;122(2):382-90. doi: 10.1016/j.ophtha.2014.08.006.
Midlife migraine and late-life parkinsonism: AGES-Reykjavik study.
Scher AI, Ross GW, Sigurdsson S, Garcia M, Gudmundsson LS, Sveinbjörnsdóttir S, Wagner AK, Gudnason V, Launer LJ. Neurology. 2014 Sep 30;83(14):1246-52. doi: 10.1212/WNL.0000000000000840.
Birth size and brain function 75 years later.
Muller M, Sigurdsson S, Kjartansson O, Jonsson PV, Garcia M, von Bonsdorff MB, Gunnarsdottir I, Thorsdottir I, Harris TB, van Buchem M, Gudnason V, Launer LJ. Pediatrics. 2014 Oct;134(4):761-70. doi: 10.1542/peds.2014-1108.
The prevalence of aortic stenosis in the elderly in Iceland and predictions for the coming decades: the AGES-Reykjavík study.
Danielsen R, Aspelund T, Harris TB, Gudnason V. Int J Cardiol. 2014 Oct 20;176(3):916-22. doi: 10.1016/j.ijcard.2014.08.053.
Circulating sclerostin associated with vertebral bone marrow fat in older men but not women.
Ma YH, Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Eiriksdottir G, Hauksdottir AM, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Napoli N, Palermo L, Gudnason V, Li X. J Clin Endocrinol Metab. 2014 Dec;99(12):E2584-90. doi: 10.1210/jc.2013-4493.
Pulse pressure relation to aortic and left ventricular structure in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.
Torjesen AA, Sigurðsson S, Westenberg JJ, Gotal JD, Bell V, Aspelund T, Launer LJ, de Roos A, Gudnason V, Harris TB, Mitchell GF. Hypertension. 2014 Oct;64(4):756-61. doi: 10.1161/HYPERTENSIONAHA.114.03870.
Segmental kidney volumes measured by dynamic contrast-enhanced magnetic resonance imaging and their association with CKD in older people.
Woodard T, Sigurdsson S, Gotal JD, Torjesen AA, Inker LA, Aspelund T, Eiriksdottir G, Gudnason V, Harris TB, Launer LJ, Levey AS, Mitchell GF. Am J Kidney Dis. 2015 Jan;65(1):41-8. doi: 10.1053/j.ajkd.2014.05.017.
The alcohol paradox: light-to-moderate alcohol consumption, cognitive function, and brain volume.
Davis BJ, Vidal JS, Garcia M, Aspelund T, van Buchem MA, Jonsdottir MK, Sigurdsson S, Harris TB, Gudnason V, Launer LJ. J Gerontol A Biol Sci Med Sci. 2014 Dec;69(12):1528-35. doi: 10.1093/gerona/glu092.
Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
Muller M, Sigurdsson S, Kjartansson O, Aspelund T, Lopez OL, Jonnson PV, Harris TB, van Buchem M, Gudnason V, Launer LJ; Age, Gene/Environment Susceptibility-Reykjavik Study Investigators. Neurology. 2014 Jun 17;82(24):2187-95. doi: 10.1212/WNL.0000000000000517.
Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study.
Jonasson F, Fisher DE, Eiriksdottir G, Sigurdsson S, Klein R, Launer LJ, Harris T, Gudnason V, Cotch MF. Ophthalmology. 2014 Sep;121(9):1766-72. doi: 10.1016/j.ophtha.2014.03.013.
Structural MRI correlates of apathy symptoms in older persons without dementia: AGES-Reykjavik Study.
Grool AM, Geerlings MI, Sigurdsson S, Eiriksdottir G, Jonsson PV, Garcia ME, Siggeirsdottir K, Harris TB, Sigmundsson T, Gudnason V, Launer LJ. Neurology. 2014 May 6;82(18):1628-35. doi: 10.1212/WNL.0000000000000378.
Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study.
Qiu C, Sigurdsson S, Zhang Q, Jonsdottir MK, Kjartansson O, Eiriksdottir G, Garcia ME, Harris TB, van Buchem MA, Gudnason V, Launer LJ. Ann Neurol. 2014 Jan;75(1):138-46. doi: 10.1002/ana.24063.
Different susceptibility of medial temporal lobe and basal ganglia atrophy rates to vascular risk factors.
de Jong LW, Forsberg LE, Vidal JS, Sigurdsson S, Zijdenbos AP, Garcia M, Eiriksdottir G, Gudnason V, van Buchem MA, Launer LJ. Neurobiol Aging. 2014 Jan;35(1):72-8. doi: 10.1016/j.neurobiolaging.2013.07.009.
Structural patterns of the proximal femur in relation to age and hip fracture risk in women.
Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ 3rd, Keyak JH, Gudnason V, Khosla S, Harris TB, Lang TF. Bone. 2013 Nov;57(1):290-9. doi: 10.1016/j.bone.2013.08.017.
Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scans.
Kopperdahl DL, Aspelund T, Hoffmann PF, Sigurdsson S, Siggeirsdottir K, Harris TB, Gudnason V, Keaveny TM. J Bone Miner Res. 2014 Mar;29(3):570-80. doi: 10.1002/jbmr.2069.
Similarities and differences between sexes in regional loss of cortical and trabecular bone in the mid-femoral neck: the AGES-Reykjavik longitudinal study.
Johannesdottir F, Aspelund T, Reeve J, Poole KE, Sigurdsson S, Harris TB, Gudnason VG, Sigurdsson G. J Bone Miner Res. 2013 Oct;28(10):2165-76. doi: 10.1002/jbmr.1960.
Fracture risk assessment in older adults using a combination of selected quantitative computed tomography bone measures: a subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study.
Rianon NJ, Lang TF, Siggeirsdottir K, Sigurdsson G, Eiriksdottir G, Sigurdsson S, Jonsson BY, Garcia M, Yu B, Kapadia AS, Taylor WC, Selwyn BJ, Gudnason V, Launer LJ, Harris TB. J Clin Densitom. 2014 Jan-Mar;17(1):25-31. doi: 10.1016/j.jocd.2013.03.005
Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults.
Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Shet K, Palermo L, Gudnason V, Li X. J Clin Endocrinol Metab. 2013 Jun;98(6):2294-300. doi: 10.1210/jc.2012-3949.
Type 3 finger length pattern is associated with total knee replacements due to osteoarthritis but not with hip replacements or hand osteoarthritis in the elderly: the AGES-Reykjavik study.
Sigurjonsdottir K, Bjorgulfsson TM, Aspelund T, Eiriksdottir G, Sigurdsson S, Ingvarsson T, Harris TB, Launer L, Gudnason V, Jonsson H. BMC Musculoskelet Disord. 2013 Mar 26;14:112. doi: 10.1186/1471-2474-14-112.
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts.
Stefansdottir H, Arnar DO, Aspelund T, Sigurdsson S, Jonsdottir MK, Hjaltason H, Launer LJ, Gudnason V. Stroke. 2013 Apr;44(4):1020-5. doi: 10.1161/STROKEAHA.12.679381.
Coronary artery calcium and physical performance as determinants of mortality in older age: the AGES-Reykjavik Study.
von Bonsdorff MB, Groffen DA, Vidal JS, Rantanen T, Jonsson PV, Garcia M, Aspelund T, Eiriksdottir G, Siggeirsdóttir K, Launer L, Gudnason V, Harris TB; Age, Gene/Environment Susceptibility–Reykjavik Study Investigators. Int J Cardiol. 2013 Oct 3;168(3):2094-9. doi: 10.1016/j.ijcard.2013.01.067.
Genetic associations with valvular calcification and aortic stenosis.
Thanassoulis G, Campbell CY, Owens DS, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, Malhotra R, O’Brien KD, Kamstrup PR, Nordestgaard BG, Tybjaerg-Hansen A, Allison MA, Aspelund T, Criqui MH, Heckbert SR, Hwang SJ, Liu Y, Sjogren M, van der Pals J, Kälsch H, Mühleisen TW, Nöthen MM, Cupples LA, Caslake M, Di Angelantonio E, Danesh J, Rotter JI, Sigurdsson S, Wong Q, Erbel R, Kathiresan S, Melander O, Gudnason V, O’Donnell CJ, Post WS; CHARGE Extracoronary Calcium Working Group. N Engl J Med. 2013 Feb 7;368(6):503-12. doi: 10.1056/NEJMoa1109034.
Proximal femoral density distribution and structure in relation to age and hip fracture risk in women.
Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ 3rd, Keyak J, Gudnason V, Khosla S, Harris TB, Lang TF. J Bone Miner Res. 2013 Mar;28(3):537-46. doi: 10.1002/jbmr.1802.
Coronary artery calcium distributions in older persons in the AGES-Reykjavik study.
Gudmundsson EF, Gudnason V, Sigurdsson S, Launer LJ, Harris TB, Aspelund T. Eur J Epidemiol. 2012 Sep;27(9):673-87. doi: 10.1007/s10654-012-9730-6.
Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults.
Schelbert EB, Cao JJ, Sigurdsson S, Aspelund T, Kellman P, Aletras AH, Dyke CK, Thorgeirsson G, Eiriksdottir G, Launer LJ, Gudnason V, Harris TB, Arai AE. JAMA. 2012 Sep 5;308(9):890-6. doi: 10.1001/2012.jama.11089.
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM; Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT Jr, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Nat Genet. 2012 Apr 15;44(5):545-51. doi: 10.1038/ng.2237.
Common variants at 6q22 and 17q21 are associated with intracranial volume.
Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT Jr, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR Jr, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen AL, Pennell CE, Thiering E, Steegers EA, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin MR, McCarthy MI, Grant SF, St Pourcain B, Timpson NJ, Smith GD, Sovio U; Early Growth Genetics Consortium, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Jaddoe VW, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH Jr, Schmidt H, Launer LJ, Breteler MM, DeCarli C; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Nat Genet. 2012 Apr 15;44(5):539-44. doi: 10.1038/ng.2245.
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study).
Johannesdottir F, Aspelund T, Siggeirsdottir K, Jonsson BY, Mogensen B, Sigurdsson S, Harris TB, Gudnason VG, Lang TF, Sigurdsson G. Calcif Tissue Int. 2012 May;90(5):354-64. doi: 10.1007/s00223-012-9585-6.
Cerebral microbleeds and age-related macular degeneration: the AGES-Reykjavik Study.
Qiu C, Cotch MF, Sigurdsson S, Eiriksdottir G, Jonasson F, Klein R, Klein BE, Harris TB, van Buchem MA, Gudnason V, Launer LJ. Neurobiol Aging. 2012 Dec;33(12):2935-7. doi: 10.1016/j.neurobiolaging.2012.01.012.
Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.
Siggeirsdottir K, Aspelund T, Jonsson BY, Mogensen B, Launer LJ, Harris TB, Sigurdsson G, Gudnason V. Age Ageing. 2012 May;41(3):351-7. doi: 10.1093/ageing/afs003.
The use of digital photographs for the diagnosis of hand osteoarthritis: the AGES-Reykjavik study.
Jonsson H, Helgadottir GP, Aspelund T, Sverrisdottir JE, Eiriksdottir G, Sigurdsson S, Eliasson GJ, Jonsson A, Ingvarsson T, Harris TB, Launer L, Gudnason V. BMC Musculoskelet Disord. 2012 Feb 16;13:20. doi: 10.1186/1471-2474-13-20.
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
O’Donnell CJ, Kavousi M, Smith AV, Kardia SL, Feitosa MF, Hwang SJ, Sun YV, Province MA, Aspelund T, Dehghan A, Hoffmann U, Bielak LF, Zhang Q, Eiriksdottir G, van Duijn CM, Fox CS, de Andrade M, Kraja AT, Sigurdsson S, Elias-Smale SE, Murabito JM, Launer LJ, van der Lugt A, Kathiresan S; CARDIoGRAM Consortium, Krestin GP, Herrington DM, Howard TD, Liu Y, Post W, Mitchell BD, O’Connell JR, Shen H, Shuldiner AR, Altshuler D, Elosua R, Salomaa V, Schwartz SM, Siscovick DS, Voight BF, Bis JC, Glazer NL, Psaty BM, Boerwinkle E, Heiss G, Blankenberg S, Zeller T, Wild PS, Schnabel RB, Schillert A, Ziegler A, Münzel TF, White CC, Rotter JI, Nalls M, Oudkerk M, Johnson AD, Newman AB, Uitterlinden AG, Massaro JM, Cunningham J, Harris TB, Hofman A, Peyser PA, Borecki IB, Cupples LA, Gudnason V, Witteman JC. Circulation. 2011 Dec 20;124(25):2855-64. doi: 10.1161/CIRCULATIONAHA.110.974899.
Brain tissue volumes in the general population of the elderly: the AGES-Reykjavik study.
Sigurdsson S, Aspelund T, Forsberg L, Fredriksson J, Kjartansson O, Oskarsdottir B, Jonsson PV, Eiriksdottir G, Harris TB, Zijdenbos A, van Buchem MA, Launer LJ, Gudnason V. Neuroimage. 2012 Feb 15;59(4):3862-3870. doi: 10.1016/j.neuroimage.2011.11.024.
Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility–Reykjavik study.
Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson Ó, Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ. Brain. 2011 Nov;134(Pt 11):3398-407. doi: 10.1093/brain/awr253.
Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik Study.
Olafsdottir E, Aspelund T, Sigurdsson G, Thorsson B, Eiriksdottir G, Harris TB, Launer LJ, Benediktsson R, Gudnason V. BMJ Open. 2011 Jun 29;1(1):e000132. doi: 10.1136/bmjopen-2011-000132.
Association of Unrecognized Myocardial Infarction With Long-term Outcomes in Community-Dwelling Older Adults: The ICELAND MI Study.
Acharya T, Aspelund T, Jonasson TF, Schelbert EB, Cao JJ, Sathya B, Dyke CK, Aletras AH, Sigurdsson S, Thorgeirsson G, Eiriksdottir G, Harris T, Launer LJ, Gudnason V, Arai AE. JAMA Cardiol. 2018 Oct 10. doi: 10.1001/jamacardio.2018.
Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study.
Hafsteinsdottir SH, Eiriksdottir G, Sigurdsson S, Aspelund T, Harris TB, Launer LJ, Gudnason V. Neurobiol Aging. 2012 Apr;33(4):829.e1-8. doi: 10.1016/j.neurobiolaging.2011.06.028.
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
Vojinovic D, Adams HH, Jian X, Yang Q, Smith AV, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, Saba Y, Luciano M, Bernard M, Trompet S, Yang J, Gillespie NA, van der Lee SJ, Neumann A, Ahmad S, Andreassen OA, Ames D, Amin N, Arfanakis K, Bastin ME, Becker DM, Beiser AS, Beyer F, Brodaty H, Bryan RN, Bülow R, Dale AM, De Jager PL, Deary IJ, DeCarli C, Fleischman DA, Gottesman RF, van der Grond J, Gudnason V, Harris TB, Homuth G, Knopman DS, Kwok JB, Lewis CE, Li S, Loeffler M, Lopez OL, Maillard P, El Marroun H, Mather KA, Mosley TH, Muetzel RL, Nauck M, Nyquist PA, Panizzon MS, Pausova Z, Psaty BM, Rice K, Rotter JI, Royle N, Satizabal CL, Schmidt R, Schofield PR, Schreiner PJ, Sidney S, Stott DJ, Thalamuthu A, Uitterlinden AG, Valdés Hernández MC, Vernooij MW, Wen W, White T, Witte AV, Wittfeld K, Wright MJ, Yanek LR, Tiemeier H, Kremen WS, Bennett DA, Jukema JW, Paus T, Wardlaw JM, Schmidt H, Sachdev PS, Villringer A, Grabe HJ, Longstreth WT, van Duijn CM, Launer LJ, Seshadri S, Ikram MA, Fornage M. Nat Commun. 2018 Sep 26;9(1):3945. doi: 10.1038/s41467-018-06234-w. PMID: 30258056
Hand Osteoarthritis Severity is Associated with Total Knee Joint Replacements Independently of BMI. The Ages-Reykjavik Study.
Jonsson H, Helgadottir GP, Aspelund T, Eiriksdottir G, Sigurdsson S, Siggeirsdottir K, Ingvarsson T, Harris TB, Launer L, Gudnason V. Open Rheumatol J. 2011 Jan 13;5:7-12. doi: 10.2174/1874312901105010007.
Distribution of cortical bone in the femoral neck and hip fracture: a prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study.
Johannesdottir F, Poole KE, Reeve J, Siggeirsdottir K, Aspelund T, Mogensen B, Jonsson BY, Sigurdsson S, Harris TB, Gudnason VG, Sigurdsson G. Bone. 2011 Jun 1;48(6):1268-76. doi: 10.1016/j.bone.2011.03.776.
The presence of total knee or hip replacements due to osteoarthritis enhances the positive association between hand osteoarthritis and atherosclerosis in women: the AGES-Reykjavik study.
Jonsson H, Helgadottir GP, Aspelund T, Eiriksdottir G, Sigurdsson S, Siggeirsdottir K, Ingvarsson T, Harris TB, Launer L, Gudnason V. Ann Rheum Dis. 2011 Jun;70(6):1087-90. doi: 10.1136/ard.2010.144980.
Associations of visceral and liver fat with the metabolic syndrome across the spectrum of obesity: the AGES-Reykjavik study.
Kim LJ, Nalls MA, Eiriksdottir G, Sigurdsson S, Launer LJ, Koster A, Chaves PH, Jonsdottir B, Garcia M, Gudnason V, Harris TB; AGES-Reykjavik Study Investigators. Obesity (Silver Spring). 2011 Jun;19(6):1265-71. doi: 10.1038/oby.2010.291.
Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study.
Jonasson F, Arnarsson A, Eiríksdottir G, Harris TB, Launer LJ, Meuer SM, Klein BE, Klein R, Gudnason V, Cotch MF. Ophthalmology. 2011 May;118(5):825-30. doi: 10.1016/j.ophtha.2010.08.044.
Analysing the large decline in coronary heart disease mortality in the Icelandic population aged 25-74 between the years 1981 and 2006.
Aspelund T, Gudnason V, Magnusdottir BT, Andersen K, Sigurdsson G, Thorsson B, Steingrimsdottir L, Critchley J, Bennett K, O’Flaherty M, Capewell S. PLoS One. 2010 Nov 12;5(11):e13957. doi: 10.1371/journal.pone.0013957.
Correlation of echocardiographic findings with cerebral infarction in elderly adults: the AGES-Reykjavik study.
McAreavey D, Vidal JS, Aspelund T, Owens DS, Hughes T, Garcia M, Sigurdsson S, Bjornsdottir H, Harris TB, Gudnason V, Launer LJ, Plehn JF. Stroke. 2010 Oct;41(10):2223-8. doi: 10.1161/STROKEAHA.110.590430.
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study.
Vidal JS, Sigurdsson S, Jonsdottir MK, Eiriksdottir G, Thorgeirsson G, Kjartansson O, Garcia ME, van Buchem MA, Harris TB, Gudnason V, Launer LJ. Stroke. 2010 May;41(5):891-7. doi: 10.1161/STROKEAHA.110.579581.
Ventricular dilation: association with gait and cognition.
Palm WM, Saczynski JS, van der Grond J, Sigurdsson S, Kjartansson O, Jonsson PV, Eiriksdottir G, Gudnason V, Admiraal-Behloul F, Launer LJ, van Buchem MA; Age, Gene/Environment Susceptibility-Reykjavik Study. Ann Neurol. 2009 Oct;66(4):485-93. doi: 10.1002/ana.21739.
Migraine headache in middle age and late-life brain infarcts.
Scher AI, Gudmundsson LS, Sigurdsson S, Ghambaryan A, Aspelund T, Eiriksdottir G, van Buchem MA, Gudnason V, Launer LJ. JAMA. 2009 Jun 24;301(24):2563-70. doi: 10.1001/jama.2009.932.
Glycemic status and brain injury in older individuals: the age gene/environment susceptibility-Reykjavik study.
Saczynski JS, Siggurdsson S, Jonsson PV, Eiriksdottir G, Olafsdottir E, Kjartansson O, Harris TB, van Buchem MA, Gudnason V, Launer LJ. Diabetes Care. 2009 Sep;32(9):1608-13. doi: 10.2337/dc08-2300.
Microvascular lesions in the brain and retina: The age, gene/environment susceptibility-Reykjavik study.
Qiu C, Cotch MF, Sigurdsson S, Klein R, Jonasson F, Klein BE, Garcia M, Jonsson PV, Harris TB, Eiriksdottir G, Kjartansson O, van Buchem MA, Gudnason V, Launer LJ. Ann Neurol. 2009 May;65(5):569-76. doi: 10.1002/ana.21614.
Abnormal T-wave axis is associated with coronary artery calcification in older adults.
Scherer ML, Aspelund T, Sigurdsson S, Detrano R, Garcia M, Mitchell GF, Launer LJ, Thorgeirsson G, Gudnason V, Harris TB. Scand Cardiovasc J. 2009 Aug;43(4):240-8. doi: 10.1080/14017430802471483.
Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women.
Rosano C, Sigurdsson S, Siggeirsdottir K, Phillips CL, Garcia M, Jonsson PV, Eiriksdottir G, Newman AB, Harris TB, van Buchem MA, Gudnason V, Launer LJ. Neurobiol Aging. 2010 Jul;31(7):1197-204. doi: 10.1016/j.neurobiolaging.2008.08.004.
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study.
Qiu C, Cotch MF, Sigurdsson S, Garcia M, Klein R, Jonasson F, Klein BE, Eiriksdottir G, Harris TB, van Buchem MA, Gudnason V, Launer LJ. Diabetes. 2008 Jun;57(6):1645-50. doi: 10.2337/db07-1455.
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